Yes. Federal 49 CFR 383.31 requires a CDL holder to notify their employer within 30 days of any traffic conviction, including DUI, in any state and in any vehicle. Notification of arrest or citation is separately required within one business day if the citation leads to license suspension. Failure to notify is itself a federal violation and grounds for termination independent of the DUI itself. The chicagoduilawyer.net brand counsels clients to consult defense counsel before the employer conversation, but never to hide the event: the record follows the license through the Commercial Driver License Information System and will surface.
